Systems Pharmacology IV

Review of the functional organization of the central nervous system. Local anesthetics, Theories of general anaesthesia. General anaesthetic agents. Pre-anaesthetic medication. Hypnotics and sedatives. Centrally acting muscle relaxants. Alcohol and alcohol abuse. CNS stimulants and anticonvulsants. Drugs used in parkinson’s disease. Drugs used in other neurodegenerative diseases. Antipsychotics. Antidepressants and mood stabilizing drugs. Opioid analgesics, antagonists and drug dependence. Non-steroidal anti-inflammatory analgesics. Antiepileptic drugs. Immunopharmacology: Overview of immune response. Role of cytokins in immune response. Immunosuppresants in organ transplantation and autoimmune diseases – calcineurin inhibitors, antiproliferative drugs, glucocorticoids and antibodies. Monoclonal antibodies as therapeutic agents.