Physical Pharmaceutical Chemistry

Physical Chemistry: Review of principles of thermodynamics and chemical kinetics relevant to pharmacy. Effect of these on the feasibility of drug synthesis, mixing, solubility, biological redox systems.

Chemical and ionic equilibria: Acid-base Equilibria, ionic activity, solubility and hydrolysis, theory of indicators, ionization constants, pH and buffer solutions.

Introductory analytical methods: Concepts of purity, limit tests, melting points and separation techniques.

Physicochemical properties of drug molecules: Optical activity, adsorption, melting point, dipole moment, viscosity etc. Introduction to UV-Spectrometry, Beer’s plot and other methods of analysis.