Medicinal Chemistry and Drug Design

Drug design: Physico-chemical approaches to drug design. Historical, Free-Wilson and Hansch approaches. The concept of isosterism. Bioisosterism as a tool in drug design. SAR in drug design. Anti-metabolite and pro-drug approach to design a new drug. Drug development: Stages in drug development. Paradigms in drug discovery and development. Computational drug design: Chemoinformatics and bioinformatics: applications in drug design and development, molecular modeling, virtual screening, Docking, molecular dynamics and Monte Carlos quantum methods.