Genetic and Tissue Engineering

Genetic engineering has revolutionized biological and medical sciences. The first example was the manufacturing of human insulin in bacteria. In this course, genetic engineering is applied to understand the biological, medical and engineering aspects of immunology. Immunochemistry deals with biochemical molecules of antibodies, T cell receptors for antigens, major histocompatibility complex class I and II molecules, cluster of differentiation molecules, stem cells etc. Basic mechanisms of vaccination will be analyzed using detailed differential equations, with special emphasis on influenza, HIV, and cancer. This course will train students in advanced cellular and tissue engineering methods that apply physical, mechanical and chemical manipulation of materials in order to direct cell and tissue function, production and bioprinting of tissue scaffolds from nanocomposites. Students will learn the techniques and equipment of bench research including cell culture, immunofluorescent imaging, soft lithography, variable stiffness substrates, application/measurement of forces and other methods. Students will integrate classroom lectures and lab skills by applying the scientific method to develop a unique project while working in a team environment, keeping a detailed lab notebook and meeting mandated milestones. Emphasis will be placed on developing the written and oral communication skills required of the professional scientist. The class will culminate with a poster presentation session based on class projects.