Biopharmaceutics

Fate of the drug after administration, process of drug disposition, structure and properties of biological membranes, membrane models, pH-partition principles, blood-brain and blood-CSF barriers. Physical significance of drug concentration in the blood; Biological factors in drug absorption; Physicochemical factors affecting drug absorption; Dosage form consideration in gastrointestinal absorption; Drug-drug and drug-food interactions, bioavailability and bioequivalence with emphasis on product registration with regulatory bodies. Problems associated with pre-formulation of drugs and the design of dosage forms from an industrial perspective. Routes of drug bioavailability, Drug-protein binding, Enzymology and enzyme Kinetics, drug-receptor and bioenergetics, Consideration of the process of drug disposition and fate. Assessment of bioavailability. Problems associated with pre-formation of drugs and design of dosage forms from an industrial perspective. Biopharmaceutics classification system (BCS), Organ-based BCS e.g. pulmonary BCS (pBCS). Biopharmaceutics and drug disposition.