Preservation and Fermentation Biotechnology

General principles of spoilage and preservation against biodegradation. Raw materials quality. Water and its purity. In-process microbiological controls. Quality Assurance of finished products. Limiting number of viable organisms. Principles of preservation of multiphase systems. Factory and Hospital hygiene. Code of Good Pharmaceutical Manufacturing Practice (GPMP). Fundamentals of industrial fermentation. Use of microorganisms in biotechnology. Search for cultures. Approaches in strain development. Genetic/enzymatic engineering techniques. Selective isolation of mutants. Maintenance and preservation. Media development and processing. Fermentation and product recovery. Primary and secondary metabolites. Clinical trials registration. Intellectual property and patent rights of biotechnological products. Infectious diseases and pathogenesis. Current drug therapies for HIV/AIDS and its associated opportunistic infections. The psychological aspects of HIV pharmaceutical services will be discussed with emphasis on the role of the pharmacist as HIV/AIDS counselor/educator. Infections, mechanisms of infections, host-parasite relationship, transmission of infections. Pathogenesis. Human pathogenic bacteria. Identification and infection patterns of Gram negative and Gram positive organisms. Urinary tract, GIT and respiratory tract infections.