Clinical Chemistry I

Porphyrin, causes, symptoms and laboratory investigation of porphyrinaemia, porphria and Porphyrinuria, Haemoglobin, synthesis, function. Glycosylated haemoglobins. Abnormal haemoglobins, haemoglobinopathics, Sulp Hb, CoHb,Hb, Liver Function Tests.

Mechanism of Enzyme action and kinetics: Clinical Enzymology; Isoenzymes in medicine, Coenzymes and Vitamins. Definition, causes, consequences and investigation of some inborn errors of metabolism; Phenylketonuria, galactosaemia fructose intolerance, Albinism, aminoacidurias, Endocrine glands and functions; the hypothalamus, the pituitary, the parathyroid, adrenal cortex, adrenal medulla, the gonads and reproductive endocrinology. Foeto-placental function. Calcium and bone metabolism. Pancreatic function tests. Basic neurochemistry, CSF – normal composition and changes in disease.